Prognostic factors and treatment outcome in childhood acute lymphoblastic leukemia

Introduction. Acute lymphoblastic leukemia is ? malignant, clonal proliferation of B or T lymphocyte precursors. Prognostic factors play an important role in the treatment this disease. The objective study was to determine whether individual clinical and laboratory parameters may have a predictive significance for relapse disease outcome. Material Methods. A retrospective included 53 patients with acute treated at Institute Child Youth Health Care Vojvodina. following were examined: gender, age diagnosis, initial white blood cell count, peripheral blast percentage, bone marrow prednisone response on day 8 treatment, immunophenotypic characteristics leukemic blasts, infiltration central nervous system. Relapses lethal outcomes analyzed as well. Results. mean diagnosis 6.4 7.8 years. associated poor outcome were: over 10 years, mature leukemia, system involvement. Relapse found 6 children (11.3%). Lethal recorded 7 (13.2%). Conclusion. Treatment childhood should be based prognostic each patient. results are consistent current literature.